Drugs that Negatively Interact with Limbitrol

Limbitrol is a medication designed to combat serious depression and anxiety. The drug is a combination of chlordiazepoxide, which is a benzodiazepine, and amitriptyline, which is a tricyclic antidepressant. Benzodiazepine medications are central nervous system depressants, which means that they reduce the firing of neurons and slow neuronal activity by changing the balance of neurotransmitters like dopamine in the brain.

Many benzodiazepine medications are prescribed to treat anxiety, especially in individuals who have had a sudden surge of anxiety leading to panic attacks. They are typically prescribed for short-term use, because benzodiazepines are also very habit-forming.

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Drugs that Interact with Limbitrol

  • Alcohol
  • Narcotic pain relievers
  • Other benzodiazepines
  • Other antidepressant medications
  • Cigarettes

Tricyclic antidepressants control and change the balance of neurotransmitters, although they are not prescribed as often as more recently developed antidepressant medications because of the number of side effects. Tricyclic antidepressants can also, rarely, lead to serotonin syndrome, in which the brain is flooded with too much serotonin. Symptoms of serotonin syndrome include raised heartbeat, restlessness, confusion, sweating, tremors, and loss of coordination.

Because Limbitrol contains two powerful chemicals, the medication can be very habit-forming, and it can also interact with numerous other medications. Some of these interactions can increase the risk of physical dependence, addiction, or overdose.


Alcohol is a legal and widely available central nervous system (CNS) depressant. Like benzodiazepines, alcohol leads to feeling relaxed, somewhat euphoric, and less inhibited. Both benzodiazepines and alcohol also, in large doses, lead to confusion, loss of coordination, slurred speech, nausea and vomiting, and other symptoms of “acting drunk.” Mixing CNS depressants is never a good idea, and it is especially recommended against mixing benzodiazepines and alcohol, because they can greatly enhance each other’s effects. If a person mixes these two CNS depressants, particularly for nonmedical or intentionally illicit reasons, they could experience sedation from which they may not wake up.Additionally, alcohol and antidepressants do not mix well. This can lead to dizziness, seizures, confusion or delirium, and coma. It also increases the person’s risk of serotonin syndrome.

Narcotic pain relievers

Prescription pain medications, like oxycodone, hydrocodone, fentanyl, morphine, and more, do not mix well with either benzodiazepines. Both are CNS depressant medications, and when combined, the person may become extremely drowsy or sleepy. Benzodiazepines may also enhance narcotics’ potential to reduce breathing, which can lead to severely depressed breathing or even stopped breathing, while the individual is unconscious.

Other benzodiazepinesThis combination increases the bioavailability of benzodiazepines, especially when mixing two types with different half-lives. They will compound each other’s side effects and can cause overdose much more quickly.

Other antidepressant medicationsMixing two tricyclic antidepressants, or a tricyclic and an SSRI antidepressant, is actually a common solution for the one-third of people struggling with depression who find that one antidepressant does not work well enough. However, these medications should only be combined with a doctor’s oversight, because they can increase side effects, and lead to serotonin syndrome. MAO inhibitors can interact dangerously with Limbitrol. Neither drug should be taken within 14 days of the other, because this can cause extremely high blood pressure and seizures.

CigarettesSmoking tobacco reduces the body’s ability to use chlordiazepoxide, which could lead to abuse if the individual believes the dose is not working and takes more than prescribed.

Muscle relaxants and tranquilizersThese are also CNS depressants. Barbiturates and sleep medications should not be used in combination with other medications that cause similar effects, because the effects will compound each other and lead to drowsiness, memory loss, loss of physical coordination, “acting drunk,” and potentially stupor or unconsciousness.

The Danger of Mixing Substances

People who struggle with addiction to prescription medications, including Limbitrol, as well as alcohol, cigarettes, and more can accidentally or intentionally mix medications, which can lead to serious side effects. In many instances, people who struggle with alcohol or cigarette addiction may unknowingly mix prescription medications and suffer side effects; in other cases, people struggling with polydrug addiction may intentionally mix different combinations of drugs to achieve a more intense high, but this can also lead to dangerous side effects.
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Editorial Staff
Editorial Staff, American Addiction Centers
The editorial staff of Sunrise House is comprised of addiction content experts from American Addiction Centers. Our editors and medical reviewers have over a decade of cumulative experience in medical content editing and have reviewed thousands... Read More